Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1.

@article{Klok1998InductionAM,
  title={Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1.},
  author={Elisabeth J. Klok and N. H. Lubsen and Coral G. Chamberlain and John W. McAvoy},
  journal={Experimental eye research},
  year={1998},
  volume={67 4},
  pages={
          425-31
        }
}
The differentiation of rat lens epithelial cells to fibre cells can be mimicked using lens epithelial explants, which differentiate in vitro when exposed to fibroblast growth factor (FGF). A previous study demonstrated that FGF is required only for initiation of differentiation: once induced by FGF, differentiation can be maintained by insulin (as assessed by following the accumulation of fibre-cell specific crystallins). The aim of this investigation was to determine whether insulin-like… CONTINUE READING
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