Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance.

@article{Palomares2012InductionAM,
  title={Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance.},
  author={Oscar Palomares and Beate Rueckert and Tuomas Jartti and Umut Can K{\"u}c{\"u}ksezer and Tuomo Puhakka and Enrique G{\'o}mez and Heinz Benedikt Fahrner and Andreas Speiser and Andreas Jung and William W Kwok and Livije Kalogjera and M{\"u}beccel Akdis and Cezmi A. Akdis},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 2},
  pages={510-20, 520.e1-9}
}
BACKGROUND Tonsils are strategically located in the gateway of both alimentary and respiratory tracts representing the first contact point of food and aeroallergens with the immune system. Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact. OBJECTIVE The aim of this study was to demonstrate cellular and molecular mechanisms of oral tolerance induction to food and aeroallergens in human tonsils. METHODS… CONTINUE READING

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