Induction and inhibition of the allantoin permease in Saccharomyces cerevisiae

@article{Sumrada1978InductionAI,
  title={Induction and inhibition of the allantoin permease in Saccharomyces cerevisiae},
  author={Roberta A. Sumrada and C A Zacharski and Vanessa Turoscy and Terrance G. Cooper},
  journal={Journal of Bacteriology},
  year={1978},
  volume={135},
  pages={498 - 510}
}
Allantoin uptake in Saccharomyces cerevisiae is mediated by an energy-dependent, low-Km, active transport system. However, there is at present little information concerning its regulation. In view of this, we investigated the control of alloantoin transport and found that it was regulated quite differently from the other pathway components. Preincubation of appropriate mutant cultures with purified allantoate (commercial preparations contain 17% allantoin), urea, or oxalurate did not… 
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23 Citations
Background Citations
10
Results Citations
1

23 Citations

Allantoate transport in Saccharomyces cerevisiae
TLDR
It is found that, contrary to earlier reports, the reaction catalyzed by allantoinase is freely reversible and exchange of intra- and extracellular allantoate was found to occur very slowly.
Allantoin transport in Saccharomyces cerevisiae is regulated by two induction systems
TLDR
Induction is probably a transcriptionally regulated process, because addition of hydantoin acetate or oxalurate to the culture medium increased the steady-state levels of mRNA encoded by a gene required for allantoin transport (DAL4).
Regulation of allantoate transport in wild-type and mutant strains of Saccharomyces cerevisiae
TLDR
The pleiotropic behavior of the dal4 and dal5 mutations are interpreted as deriving from a functional interaction between elements of the two transport systems, which appear to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition.
Genes of Different Catabolic Pathways Are Coordinately Regulated by Dal81 in Saccharomyces cerevisiae
TLDR
Dal81, a general positive regulator of genes involved in nitrogen utilization related to the metabolisms of GABA, leucine, and allantoin, plays a central role in this coordinated regulation.
The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical
TLDR
The finding of these homologous sequences predicted to exist on the basis of DAL4's expression characteristics, supports and strengthens the suggestion that these elements mediate the functions the authors have previously ascribed to them.
Oxalurate transport in Saccharomyces cerevisiae
TLDR
Observations suggest that failure of oxalurate to bring about induction of allophanate hydrolase in cultures growing under repressive conditions does not result from inducer exclusion, but rather from repression of dur1,2 gene expression.
Ureide metabolism in higher plants
The regulation of yeast gene expression by multiple control elements.
TLDR
The purpose is the development of a model in the simple eucaryotic microorganism, Saccharomyces cerevisiae, of the metabolism of two main nitrogen sources, allantoin and arginine, and the selection of two systems instead of one to gain some insight into the spectrum of regulatory mechanisms that operate in eucarian cells.
Nitrogen catabolite repression in yeasts and filamentous fungi.
Nitrogen catabolite repression in Saccharomyces cerevisiae
TLDR
All known promoter sequences related to expression of nitrogen catabolite pathways are discussed as well as other regulatory proteins.
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References

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TLDR
Allantoin uptake in both growing and resting cultures of Saccharomyces cerevisiae occurs by a low-Km transport system that uses energy that is likely generated in the cytoplasm, based on the observation that transport did not occur in the absence of glucose or the presence of dinitrophenol, carbonyl cyanide-m-chloro-phenyl hydrazine, fluoride, or arsenate ions.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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