Induction and habituation of immediate early gene expression in rat brain by acute and repeated restraint stress.

@article{Melia1994InductionAH,
  title={Induction and habituation of immediate early gene expression in rat brain by acute and repeated restraint stress.},
  author={Kathleen R. Melia and Andrey E. Ryabinin and Richard Schroeder and Floyd E. Bloom and Michael C. Wilson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 10},
  pages={5929-38}
}
Acute exposure to stress leads to activation of the pituitary-adrenal axis (PA-axis) while repeated exposure to a homotypic stressor generally results in habituation of this response. Previous studies suggested that such habituation is largely due to changes in afferents of the PA-axis. To examine where within these afferents habituation occurs, we studied the effect of acute and repeated exposure to 2 hr restraint stress on expression of c-fos mRNA, as a marker of altered neuronal activity, in… CONTINUE READING