Induction and expression of cyclin D3 in human pancreatic cancer

  title={Induction and expression of cyclin D3 in human pancreatic cancer},
  author={Matthias P. A. Ebert and Sara Hernberg and Guo Fei and Armin A. Sokolowski and H. U. Schulz and Hans Lippert and Peter Malfertheiner},
  journal={Journal of Cancer Research and Clinical Oncology},
Purpose: Cyclins play a key role in the control and regulation of the cell cycle. The role of cyclins in the pathogenesis of pancreatic cancer is largely unknown. Methods: Using Northern blot analysis, polymerase chain reaction (PCR) and immunohistochemistry, we examined the expression of cyclins D1, D2, and D3 in human pancreatic cancer and studied the induction of these cyclins by growth factors in pancreatic cancer cell lines. Results: We now report that cyclin D1 and D3 mRNAs are expressed… 
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