Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells.

  title={Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells.},
  author={G Y Tanaka and Sachiko Kanaji and Ayumi Hirano and Kazuhiko Arima and Akira Shinagawa and Chiho Goda and Shin'ichiro Yasunaga and Koichi Ikizawa and Yukiyoshi Yanagihara and Masato Kubo and Yoshiaki Kuriyama-Fujii and Yuji Sugita and Akira Inokuchi and Kenji Izuhara},
  journal={International immunology},
  volume={17 6},
It is widely known that IL-4 and IL-13 act on various kinds of cells, including B cells, resulting in enhancement of proliferation, class switching to IgE and expression of several surface proteins. These functions are important for the recognition of the various antigens in B cells and are known to be involved in the pathogenesis of allergic diseases. However, it has not been known whether IL-4/IL-13 is involved in the metabolism of various kinds of xenobiotics including 2,3,7,8-tetra… CONTINUE READING
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