Induction and Inhibition of the Th2 Phenotype Spread: Implications for Childhood Asthma

Abstract

METHODS. To induce and characterize phenotype spread, BALB/c mice were first immunized by a series of subcutaneous injections of egg ovalbumin and then challenged intranasally with ovalbumin, ragweed, or both simultaneously. Mice were finally challenged intranasally with ragweed alone to assess allergic response (Th2-mediated lung inflammation, ragweed… (More)

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