Induction Patterns of Transcription Factors of the Nur Family (Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics in the Mouse Brain: Implication for Their Mechanism of Action

@article{Maheux2005InductionPO,
  title={Induction Patterns of Transcription Factors of the Nur Family (Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics in the Mouse Brain: Implication for Their Mechanism of Action},
  author={J{\'e}r{\^o}me Maheux and Isabelle Ethier and Claude Rouillard and Daniel L{\'e}vesque},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={313},
  pages={460 - 473}
}
Monitoring gene expression has been intensively used to identify neurobiological and neuroanatomical substrates associated with administration of antipsychotic drugs. Transcription factors of the Nur family (Nurr1, Nur77, and Nor-1) are orphan nuclear receptors that have been recently associated with dopamine neurotransmission. Nurr1 is involved in midbrain dopamine neuron development. Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal… 
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Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover
Modulation of haloperidol-induced patterns of the transcription factor Nur77 and Nor-1 expression by serotonergic and adrenergic drugs in the mouse brain.
TLDR
The ability of a 5-HT(1A) agonist or a 5,HT(2A) antagonist to reduce haloperidol-induced Nur77 and Nor-1 striatal expression is shown, suggesting that these serotonin receptor subtypes participate in the differential pattern of gene expression induced by typical and atypical antipsychotic drugs.
Nur transcription factors in stress and addiction
TLDR
The data supporting that Nur transcription factors are key players in the molecular basis of the dysregulation of neuronal circuits involved in chronic stress and addiction are reviewed.
17β-Estradiol Delays 6-OHDA-Induced Apoptosis by Acting on Nur77 Translocation from the Nucleus to the Cytoplasm
TLDR
A kinetic study on the effect of neurotoxic 6-hydroxydopamine and 17β-estradiol on the subcellular localization of Nur77 with reference to the modulation of apoptosis in PC12 cells shows an intriguing cooperation between E2 and Nur77 toward cellular fate guidance.
Role of Members of the Nur (NR4A) Transcription Factors in Dopamine-Related Neurodegenerative and Neuropsychiatric Disorders
TLDR
Interestingly, modulation of Nur gene expression can be observed in brain pathological conditions and treatment of dopamine-related disorders, as evidenced by the modulation of these transcription factors in animal models of Parkinson’s disease and schizophrenia and in post mortem human brain tissues from naïve and treated patients, suggesting that monitoring Nur expression might represent interesting biomarkers for dopamine- related disorders and their treatment.
NR4A Gene Expression Is Dynamically Regulated in the Ventral Tegmental Area Dopamine Neurons and Is Related to Expression of Dopamine Neurotransmission Genes
TLDR
The data demonstrate that the NR4A genes are dynamically regulated in dopamine neurons with maintenance of Nurr1 expression requiring dopamine neuron activity while both attenuation of dopamine autoreceptors activation and dopamine neuronal activity combining to induce Nur77 expression and suggest that induction of NR3A genes could regulate TH and DAT expression and ultimately regulate dopamine neurotransmission.
Dopamine Agonists Exert Nurr1-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease
TLDR
DA agonists can induce Nurr1 expression in PBMC, and such effect may contribute to DA agonists-mediated neuroprotection on DA neurons.
Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation
TLDR
Novel findings, which may be influenced by antipsychotic drug exposure, implicate the orphan and retinoid nuclear receptors in the cortical pathology found in schizophrenia.
Repeated Haloperidol Administration has No Effect on Vitamin D Signaling but Increase Retinoid X Receptors and Nur77 Expression in Rat Prefrontal Cortex
TLDR
It was found that haloperidol has no effect on local VD signaling, but could significantly increase Nur77, Rxrβ, and Rxrγ expression, which indicated that Nur77/Rxr, but not vdr/RXr, was implicated in dopamine-related neuroadaptation.
Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32
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