Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice.

@article{Balansky1999InductionPA,
  title={Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice.},
  author={Roumen M Balansky and F D' Agostini and Silvio L De Flora},
  journal={Carcinogenesis},
  year={1999},
  volume={20 8},
  pages={1491-7}
}
In spite of the major role played by smoking tobacco in the epidemiology of chronic degenerative diseases, it is difficult to mimic the genotoxic and carcinogenic effects of this complex mixture in animal models. We undertook an experimental study evaluating the time-course induction, persistence and modulation of cytogenetic alterations induced in BDF(1) mice exposed whole-body to mainstream cigarette smoke. The animals were divided into five groups, including: (i) 72 sham-exposed mice; (ii… CONTINUE READING
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