Induction, binding specificity and function of human ICOS.

  title={Induction, binding specificity and function of human ICOS.},
  author={Katja C. Beier and Andreas Hutloff and Anna Maria Dittrich and Carsten Heuck and Alexander Rauch and Kerstin B{\"u}chner and Burkhard Ludewig and Hans D. Ochs and Hans Werner Mages and Richard A. Kroczek},
  journal={European journal of immunology},
  volume={30 12},
Recently, we have identified the inducible co-stimulator (ICOS), an activation-dependent, T cell-specific cell surface molecule related to CD28 and CTLA-4. Detailed analysis of human ICOS presented here shows that it is a 55-60-kDa homodimer with differently N-glycosylated subunits of 27 and 29 kDa. ICOS requires both phorbol 12-myristate 13-acetate and ionomycin for full induction, and is sensitive to Cyclosporin A. ICOS is up-regulated early on all T cells, including the CD28- subset, and… CONTINUE READING