Induction, activation, and inhibition of hamster and rat liver microsomal arylamide and arylamine N-hydroxylase.

@article{Razzouk1980InductionAA,
  title={Induction, activation, and inhibition of hamster and rat liver microsomal arylamide and arylamine N-hydroxylase.},
  author={C Razzouk and Manuel Mercier and Marcel B. Roberfroid},
  journal={Cancer research},
  year={1980},
  volume={40 10},
  pages={3540-6}
}
By applying a new and highly sensitive assay for measuring N-hydroxy metabolites, the biochemical properties of the microsomal N-hydroxylase from control and 3-methylcholanthrene-treated rat and hamster liver have been analyzed, and the following conclusions have been drawn. (a) Due to a difference in enzyme affinity, the metabolic activation of acetylaminofluorene is more pronounced than that of aminofluorene, a fact which correlates with the difference in the carcinogenic potency of the two… CONTINUE READING