Induction, activation, and inhibition of hamster and rat liver microsomal arylamide and arylamine N-hydroxylase.

@article{Razzouk1980InductionAA,
  title={Induction, activation, and inhibition of hamster and rat liver microsomal arylamide and arylamine N-hydroxylase.},
  author={C. Razzouk and Michel Mercier and Marcel B. Roberfroid},
  journal={Cancer research},
  year={1980},
  volume={40 10},
  pages={
          3540-6
        }
}
By applying a new and highly sensitive assay for measuring N-hydroxy metabolites, the biochemical properties of the microsomal N-hydroxylase from control and 3-methylcholanthrene-treated rat and hamster liver have been analyzed, and the following conclusions have been drawn. (a) Due to a difference in enzyme affinity, the metabolic activation of acetylaminofluorene is more pronounced than that of aminofluorene, a fact which correlates with the difference in the carcinogenic potency of the two… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 78 REFERENCES

Species variations in the N- and ring-hydroxylation of 2-acetylaminofluorene and effects of 3-methylcholanthrene pretreatment.

  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1967
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Enzymatic deacetylation

C C.Irving.
  • on April
  • 1980
VIEW 2 EXCERPTS

Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals

S. S. Thorgeirsson, Atlas, R S.A..Boobis.A., S Filton.J.
  • Biochem. Pharmacol.
  • 1979
VIEW 1 EXCERPT

Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals

S. S. Thorgeirsson, Atlas, R S.A..Boobis.A., S Filton.J.
  • Biochem. Pharmacol.
  • 1979
VIEW 1 EXCERPT

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