Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection.

@article{Olekhnovitch2015InductionPA,
  title={Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection.},
  author={Romain Olekhnovitch and Philippe Bousso},
  journal={Trends in parasitology},
  year={2015},
  volume={31 12},
  pages={653-664}
}
The production of nitric oxide (NO) by the inducible NO synthase (iNOS) is a key defense mechanism against intracellular pathogens such as Leishmania. Numerous studies have investigated the antimicrobial properties of this small molecule in vitro but its precise mode of action during Leishmania infection in vivo is still unclear. In this review, we discuss… CONTINUE READING