Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2.

  title={Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2.},
  author={Brijesh Kumar Pandey and Saurabh Srivastava and Manish Singh and Jimut Kanti Ghosh},
  journal={The Biochemical journal},
  volume={436 3},
Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine-zipper-like sequences in melittin and other naturally occurring antimicrobial peptides. Magainin 2 shows significantly lower cytotoxicity than many naturally occurring antimicrobial peptides and lacks this structural element. To investigate the consequences of introducing a leucine zipper sequence in magainin 2, a novel analogue (Mag-mut) was designed by rearranging only the positions… 

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