Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice.

@article{Astori2000InducingTB,
  title={Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice.},
  author={Mireille Astori and Christophe von Garnier and Alexander Kettner and Nathalie Dufour and Gampietro Corradin and François Spertini},
  journal={Journal of immunology},
  year={2000},
  volume={165 6},
  pages={3497-505}
}
To assess the capacity of a peptide-based immunotherapy to induce systemic tolerance via the nasal route, we designed three long overlapping peptides of 44-60 aa covering the entire sequence of phospholipase A2 (PLA2), a major bee venom allergen. Both prophylactic and therapeutic intranasal administrations of long peptides to PLA2-hypersensitive CBA/J mice induced specific T cell tolerance to the native allergen. In prophylactic conditions, this tolerance was marked by a suppression of… CONTINUE READING