Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female rat liver.

@article{Oesch1996InducingPO,
  title={Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female rat liver.},
  author={Franz Oesch and Michael Arand and Margherita Strolin Benedetti and Maria Grazia Castelli and Philippe Dostert},
  journal={The Journal of antimicrobial chemotherapy},
  year={1996},
  volume={37 6},
  pages={1111-9}
}
Important species differences have been reported concerning the induction properties of rifampicin towards enzymes of the P-450 superfamily. Mice, rabbits and humans are far more responsive than rats and guinea pigs. In the present study a strong induction of cytochrome P-450 3A-dependent enzyme activities was observed in female rat liver microsomes after high dose treatment (> or = 250 mg/kg/day for 9 days) with rifampicin, resulting in an up to 30-fold enhanced hydroxylation rate of… CONTINUE READING

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