Inducing effect of periodontopathic bacteria on interleukin-1 production by mouse peritoneal macrophages.

  title={Inducing effect of periodontopathic bacteria on interleukin-1 production by mouse peritoneal macrophages.},
  author={Yoshihiro Ohmori and Kohei Honda and Hideo Kikuchu and Shigemasa Hanazawa and Shigeru Amano and Kimiharu Hirose and Akira Takeshita and Taiji Katoh and Shigeo Kitano},
  journal={Oral microbiology and immunology},
  volume={3 4},
Sonicated extracts from Bacteroides gingivalis. Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, and Actinomyces viscosus were found to strongly induce IL-1 production by mouse peritoneal macrophages as early as 24 h after addition of the sonicates. A significant increase in the IL-1 production was observed at a dose of 1 μg/ml (dry weight) of the sonicates. The inducing ability was equivalent to 1 μg/ml Escherichia coli lipopolysaccharide. The highest production of IL-1 was… 

Extracts of periodontopathic microorganisms lack functional superantigenic activity for murine T cells.

Results demonstrate that extracts of periodontopathic bacteria do not stimulate murine T cells in a manner consistent with superantigenic activation.

Immunomodulating Activities of Sodium-dodecyl-sulphate-extracted Antigens from Actinobacillus actinomycetemcomitans Serotype b

A mixed response of CWP-induced splenocyte stimulation and suppression, and IL-l/IL-4 release, is dependent on fragment size, which means CWP may play a role in the inflammatory process of periodontal disease as large bacterial fragments stimulate inflammation and smaller, degraded fragments promote anti-inflammatory activities.

Cytokine production induced by a 67-kDa fimbrial protein from Porphyromonas gingivalis.

The results suggest that P. gingivalis 67-kDa fimbriae may play a part in the inflammatory response during the development of periodontal diseases.

A possible mechanism of maxillofacial abscess formation: involvement of Porphyromonas endodontalis lipopolysaccharide via the expression of inflammatory cytokines.

It is suggested here that P. endodontalis lipopolysaccharide in the infectious materials plays a stimulatory role in maxillofacial abscess formation via the expression of inflammatory cytokines.

The regulatory effects of monocytes on human natural killer cells activated by lipopolysaccharides.

  • R. Lindemann
  • Biology, Medicine
    Journal of periodontal research
  • 1991
It is suggested that cell-to-cell contact is not necessary for MO to suppress NK cytotoxicity when stimulated by LPS, and the role of interleukin-1 and tumor necrosis factor (TNF) in NK suppression was studied.

Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum

This review covers what is known to date about F. nucleatum in general, such as taxonomy and biology, with special emphasis on its pathogenic potential, and its possible relationship to otherperiodontal bacteria in the development of periodontal diseases and the possible roles played by OMPs.

The heat shock response of Fusobacterium nucleatum.

Immunoblot analysis, using a panel of antibodies directed to epitopes on different known heat-shock proteins revealed cross-reactive proteins, indicating homology between Escherichia coli, Mycobacterium leprae and F. nucleatum heat shock proteins.

The effect of IL-1α and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts

The results suggest that the interaction between nifedipine and gingival inflammation might play an important role in the pathogenesis of nifEDipine-in ducedGingival overgrowth.

Immunologic mechanisms of pathogenesis in periodontal diseases: an assessment.

  • R. Ranney
  • Medicine, Biology
    Journal of periodontal research
  • 1991
Suggestions are made for studies needed to confirm suspected pathogenetic mechanisms, approach resultant targeted therapies, and test hypotheses for contrasting roles of immune reactions in different clinical expressions of periodontitis.



Functional role of interleukin 1 in periodontal disease: induction of interleukin 1 production by Bacteroides gingivalis lipopolysaccharide in peritoneal macrophages from C3H/HeN and C3H/HeJ mice

It is suggested that B-LPS-induced IL-1 may play a significant role in the pathogenesis of adult periodontal disease.

Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts

It is shown here that the fimbriae bind to the cells, which may subsequently lead to the stimulation of FTAF production by the cells.

An interleukin 1 like factor stimulates bone resorption in vitro

To determine whether purified IL-1 could stimulate connective tissue breakdown in vitro, preliminary experiments with monocyte-conditioned medium indicated that MCF could stimulate bone resorption, and this study undertook this study to verify these observations.

Spontaneous production of thymocyte-activating factor by human gingival fibroblasts and its autoregulatory effect on their proliferation

The observations suggest that gingival fibroblasts play a significant role in regulation of cell growth of lymphocytes and in their own growth under physiological conditions and in pathological states in periodontal connective tissue.

Microbial Pathogenicity Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in Human Periodontal Disease: Virulence Factors in Colonization, Survival, and Tissue Destruction

Characteristics of periodontopathic bacteria which may enable them initially to colonize the host, to survive in the periodontal pocket, and possibly to invade the gingival tissue despite potentially effective host defense systems are emphasized.

Increased thymocyte-activating factor in human gingival fluid during gingival inflammation

It is suggested that human gingival fluid contains epidermal thymocyte-activating factor or interleukin 1 or both, which may amplify the inflammatory response in periodontal tissues.

Interleukin 1 can act as a B-cell growth and differentiation factor.

  • B. PikeG. Nossal
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
The results challenge the notion that interleukin 1 is exclusively or even primarily an activating cytokine and will prove helpful for the further dissection of the respective roles of the various factors that can act on B cells.

Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta.

It is concluded that interleukin 1 beta is the major protein with OAF activity produced by lectin-stimulated peripheral blood mononuclear cells and that the m.w., isoelectric point, amino-terminal sequence, and specific activity in the thymocyte proliferation assay are the same for homogeneous OAF and interleucin 1beta.

The bacteriology of acute necrotizing ulcerative gingivitis.

It was proposed that these particular anaerobic species gained ascendency in the plaque as a result of being selected through the availability of host-derived nutrients in individuals who had undergone certain physiological and psychological stresses.