Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans.

@article{Leito1999InducingEO,
  title={Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans.},
  author={Armando Lu{\'i}s Ferreira Leit{\~a}o and Francisco Javier Enguita and Juan Luis de la Fuente and Paloma Liras and Juan F. Martin},
  journal={Journal of bacteriology},
  year={1999},
  volume={181 8},
  pages={2379-84}
}
The diamines putrescine, cadaverine, and diaminopropane stimulate cephamycin biosynthesis in Nocardia lactamdurans, in shake flasks and fermentors, without altering cell growth. Intracellular levels of the P7 protein (a component of the methoxylation system involved in cephamycin biosynthesis) were increased by diaminopropane, as shown by immunoblotting studies. Lysine-6-aminotransferase and piperideine-6-carboxylate dehydrogenase activities involved in biosynthesis of the alpha-aminoadipic… CONTINUE READING