Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells

@inproceedings{Vlkov2018InduciblyDM,
  title={Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells},
  author={Kateřina Vl{\vc}kov{\'a} and Jiri Vachtenheim and Jiri R{\'e}da and Pavel Hor{\'a}k and Lubica Ondru{\vs}ov{\'a}},
  booktitle={Journal of cellular and molecular medicine},
  year={2018}
}
Melanoma arises from neural crest-derived melanocytes which reside mostly in the skin in an adult organism. Epithelial-mesenchymal transition (EMT) is a tumorigenic programme through which cells acquire mesenchymal, more pro-oncogenic phenotype. The reversible phenotype switching is an event still not completely understood in melanoma. The EMT features and increased invasiveness are associated with lower levels of the pivotal lineage identity maintaining and melanoma-specific transcription… CONTINUE READING
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