Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity

@article{Thomson2010InducibleSO,
  title={Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity},
  author={Travis C Thomson and Joshua H Johnson},
  journal={Cell Death and Differentiation},
  year={2010},
  volume={17},
  pages={1717-1727}
}
We show here that similar to starvation, ingestion of the bacterial product rapamycin (RAP) interferes with egg production in female Drosophila. RAP ingestion results in posterior follicle cells (PFC) in stage 8/9 egg chambers losing epithelial polarity, after which PFC invade and phagocytose the oocyte. Nurse cell apoptosis then occurs, followed by total egg chamber destruction. Knockdown of the RAP receptor FKBP12 specifically in PFC rescues oogenesis and also the laying of embryos that… CONTINUE READING