Inducible site-specific recombination in the brain.

@article{Kellendonk1999InducibleSR,
  title={Inducible site-specific recombination in the brain.},
  author={Christoph Kellendonk and François Tronche and Emilio Casanova and Katrin Anlag and Christian Opherk and G. Sch{\"u}tz},
  journal={Journal of molecular biology},
  year={1999},
  volume={285 1},
  pages={175-82}
}
The Cre/loxP recombination system allows the generation of tissue-specific somatic mutations in mice. Additional temporal control of somatic mutagenesis is highly desirable, as this would permit a more precise analysis of gene function in complex systems such as the central nervous system. Extending our previous studies, we compared several ligand-regulated recombinases, in which the ligand-binding domain (LBD) of the progesterone receptor or the estrogen receptor was fused to the Cre… CONTINUE READING

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