Inducible resistance to D-cycloserine in Bacillus subtilis 168.

  title={Inducible resistance to D-cycloserine in Bacillus subtilis 168.},
  author={Virginia L. Clark and Frank E. Young},
  journal={Antimicrobial agents and chemotherapy},
  volume={11 5},
Resistance to d-cycloserine could be induced in Bacillus subtilis 168 by sublethal concentrations of d-cycloserine. Sensitivity to the antibiotic could be regained by growth in the absence of d-cycloserine. The bactericidal activity of d-cycloserine apparently was not altered by resistant cells, and peptidoglycan synthesis was still inhibited by d-cycloserine in resistant cells. The d-cycloserine resistance apparently resulted from a decreased uptake of the antibiotic. The decrease in d… CONTINUE READING

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