Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

@article{Maxwell1993InducibleOO,
  title={Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.},
  author={Patrick Henry Maxwell and Christopher W Pugh and Peter J Ratcliffe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 6},
  pages={2423-7}
}
Adaptive responses to hypoxia occur in many biological systems. A well-characterized example is the hypoxic induction of the synthesis of erythropoietin, a hormone which regulates erythropoiesis and hence blood oxygen content. The restricted expression of the erythropoietin gene in subsets of cells within kidney and liver has suggested that this specific oxygen-sensing mechanism is restricted to specialized cells in those organs. Using transient transfection of reporter genes coupled to a… CONTINUE READING

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