Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells.

@article{Bonfoco1998InducibleNE,
  title={Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells.},
  author={Emanuela Bonfoco and Patrick M Stuart and Thomas Levin Brunner and Tesu Lin and Thomas S Griffith and Yunfei Gao and Hiroshi Nakajima and Pierre A. Henkart and Thomas Arnold Ferguson and Douglas R Green},
  journal={Immunity},
  year={1998},
  volume={9 5},
  pages={
          711-20
        }
}
Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)-induced peripheral deletion of Vbeta8+ T cells. We found that peripheral deletion was defective in radiation chimeras with non-functional tissue FasL, regardless of the FasL status of the bone marrow-derived cells. SEB induced a dramatic upregulation of FasL expression and function in nonlymphoid cells of liver and small intestine. This effect was resistant to inhibition by cyclosporin A, which also failed… CONTINUE READING
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