Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy.

@article{Yocum2009InducibleNO,
  title={Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy.},
  author={Gene T Yocum and John G. Gaudet and Susie S. Lee and Yaakov Stern and Lauren A. Teverbaugh and Robert R. Sciacca and Charles W. Emala and Donald O. Quest and Paul C Mccormick and James F. McKinsey and Nicholas J. Morrissey and Robert A. Solomon and E. Sander Connolly and Eric J. Heyer},
  journal={Stroke},
  year={2009},
  volume={40 5},
  pages={1597-603}
}
BACKGROUND AND PURPOSE Cognitive dysfunction occurs in 9% to 23% of patients during the first month after carotid endarterectomy (CEA). A 4-basepair (AAAT) tandem repeat polymorphism (either 3 or 4 repeats) has been described in the promoter region of inducible nitric oxide synthase (iNOS), a gene with complex roles in ischemic injury and preconditioning against ischemic injury. We investigated whether the 4-repeat variant (iNOS(+)) affects the incidence of cognitive dysfunction after CEA… CONTINUE READING