Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells.

@article{Ko2008InducibleNO,
  title={Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells.},
  author={Seung Hyun Ko and Gyeong Ryul Ryu and SeungBum Kim and Yu Bae Ahn and K N Yoon and Hideaki Kaneto and Hunjoo Ha and Yu Seun Kim and Ki-ho Song},
  journal={Transplantation},
  year={2008},
  volume={85 3},
  pages={323-30}
}
BACKGROUND Islet transplantation is a potential strategy to cure type 1 diabetes mellitus. However, a substantial part of the islet graft becomes nonfunctional due to several factors including hypoxia. However, the precise mechanism of cell damage is largely unknown in hypoxic exposure to pancreatic beta cells. The aim of the present study was to investigate whether acute and severe hypoxic injury could involve inducible nitric oxide synthase (iNOS)-nitric oxide (NO) signaling in beta cells… CONTINUE READING

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