Inducible nitric oxide synthase is involved in the mechanisms of cocaine enhanced neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat.

@article{Bagetta2004InducibleNO,
  title={Inducible nitric oxide synthase is involved in the mechanisms of cocaine enhanced neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat.},
  author={Giacinto Bagetta and Silvia Piccirilli and Claudio Del Duca and Luigi Antonio Morrone and Laura Rombol{\`a} and Giuseppe Nappi and J M de Alba and Richard Graham Knowles and Maria Tiziana Corasaniti},
  journal={Neuroscience letters},
  year={2004},
  volume={356 3},
  pages={183-6}
}
Cocaine, often abused by human immunodeficiency virus (HIV) infected patients, has been suggested to worsen the HIV associated dementia via unknown mechanisms. Here we report that subchronic treatment with a dose of cocaine (30 mg/kg i.p.), unable per se to cause neuronal death, increases the number of apoptotic cells typically observed in the neocortex of rats treated with HIV-1 gp120 (100 ng given i.c.v.). A pre-treatment with MK801 (0.3 mg/kg i.p.), a NMDA receptor antagonist, L-NAME (10 mg… CONTINUE READING
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