Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.

@article{Sinz1999InducibleNO,
  title={Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.},
  author={Elizabeth H. Sinz and Patrick M Kochanek and Clifton Edward Dixon and Robert B. Clark and Joseph Carcillo and Joanne K Schiding and M Chen and Stephen R. Wisniewski and Timothy M. Carlos and Dic Williams and S. T. DeKosky and Simon C. Watkins and Donald W. Marion and Timothy R Billiar},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 5},
  pages={647-56}
}
Nitric oxide (NO) derived from the inducible isoform of NO synthase (iNOS) is an inflammatory product implicated both in secondary damage and in recovery from brain injury. To address the role of iNOS in experimental traumatic brain injury (TBI), we used 2 paradigms in 2 species. In a model of controlled cortical impact (CCI) with secondary hypoxemia, rats were treated with vehicle or with 1 of 2 iNOS inhibitors (aminoguanidine and L-N-iminoethyl-lysine), administered by Alzet pump for 5 days… CONTINUE READING

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