Inducible nitric oxide synthase haplotype associated with migraine and aura

  title={Inducible nitric oxide synthase haplotype associated with migraine and aura},
  author={Thiago de O. S. Mansur and Flavia Magazoni Gonçalves and Alisson Martins-Oliveira and Jos{\'e} Geraldo Speciali and Fab{\'i}ola {\'E}. Dach and Riccardo Lacchini and Jos{\'e} Eduardo Tanus-Santos},
  journal={Molecular and Cellular Biochemistry},
Migraine is a complex neurological disorder with a clear neurogenic inflammatory component apparently including enhanced nitric oxide (NO) formation. Excessive NO amounts possibly contributing to migraine are derived from increased expression and activity of inducible NO synthase (iNOS). We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C−1026A—rs2779249 and G2087A—rs2297518) are associated with migraine with or without aura. We studied 142 healthy… CONTINUE READING


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Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache

  • HO Hoivik, BE Laurijssens, +6 authors MW Lunnon
  • Mol Cell Biochem
  • 2010
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