Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury.

@article{Enkhbaatar2003InducibleNO,
  title={Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury.},
  author={Perenlei Enkhbaatar and Kazunori Apt. Murakami and Katsumi Shimoda and Akio Mizutani and Lillian D. Traber and Gary Lee Phillips and J. Parkinson and John R. Salsbury and Nettie Biondo and Frank C. Schmalstieg and Ann Burke and Robert A. Cox and Hal K. Hawkins and DavidN. Herndon and Daniel Lee Traber},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 6},
  pages={
          H2430-6
        }
}
Inducible nitric oxide synthase (iNOS) is implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). ARDS treatment is frequently complicated by significant extrapulmonary comorbidity. This study was designed to clarify the role of iNOS in mediating extrapulmonary comorbidity in sheep after combined burn and smoke inhalation injuries using a potent and highly selective iNOS dimerization inhibitor, BBS-2. Twenty-two female sheep were operatively prepared. After 5 days of… CONTINUE READING

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