Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival.

@article{Krncke2001InducibleNO,
  title={Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival.},
  author={K. Kr{\"o}ncke and K. Fehsel and C. Suschek and V. Kolb-Bachofen},
  journal={International immunopharmacology},
  year={2001},
  volume={1 8},
  pages={
          1407-20
        }
}
Studies from many laboratories have demonstrated the complex role of NO in inflammatory processes. Prolonged exposure to NO shifts the cellular redox potential to a more oxidized state and this is critically regulated by intracellular levels of reduced glutathione. NO-mediated stress will alter gene expression patterns, and the number of genes known to be involved is steadily increasing. Indeed, due to its S-nitrosating activity in the presence of oxygen, NO can modify the activity of… Expand
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