Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis.

@article{Leib1998InducibleNO,
  title={Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis.},
  author={Stephen L Leib and Young Sil Kim and S. M. Black and Jay H Tureen and Martin George T{\"a}uber},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={177 3},
  pages={692-700}
}
This study explored the role of inducible nitric oxide (NO) synthase (iNOS) in an infant rat model of group B streptococcal meningitis. Brain iNOS activity increased during meningitis (P < .001), and iNOS was detected by immunocytochemistry in the walls of meningeal vessels and cells of the cerebrospinal fluid (CSF) inflammation. Animals treated with iNOS inhibitor aminoguanidine (AG; 130 mg/kg every 8 h) had reduced NO production (P < .05), higher CSF bacterial titers (P < .05), and increased… CONTINUE READING