Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis.

@article{Huang2012InducibleNO,
  title={Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis.},
  author={Guan-Jhong Huang and Jeng-Shyan Deng and Jung-Chun Liao and Wen-Chi Hou and Sheng-Yang Wang and Ping-Jyun Sung and Yueh-Hsiung Kuo},
  journal={Journal of agricultural and food chemistry},
  year={2012},
  volume={60 7},
  pages={
          1673-81
        }
}
In this study, we have investigated the anti-inflammatory effects of imperatorin, a compound isolated from the roots of Glehnia littoralis, using a lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) in vitro and a carrageenan (Carr)-induced mouse paw edema model in vivo. When RAW264.7 macrophages were treated with imperatorin together with LPS, a significant concentration-dependent inhibition of NO production was detected. Western blotting revealed that imperatorin blocked the… 
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