Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide.

@article{Panaro1999InducibleNO,
  title={Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide.},
  author={Maria Antonietta Panaro and Angela Acquafredda and Simonetta Lisi and Dario Domenico Lofrumento and Teresa Trotta and Rosa Satalino and Matteo Saccia and Vincenzo Mitolo and Olga Brandonisio},
  journal={International journal of clinical & laboratory research},
  year={1999},
  volume={29 3},
  pages={122-7}
}
Nitric oxide produced by an inducible nitric oxide synthase constitutes one of the main microbicidal mechanisms of murine macrophages and its importance is now being recognized for human macrophages. In this study we evaluated inducible nitric oxide synthase expression, nitric oxide release, and parasitocidal ability of Leishmania infantum-infected monocyte-derived human macrophages. The inducible nitric oxide synthase was detected by immunofluorescence and western blotting and nitric oxide… CONTINUE READING

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