Inducible nitric oxide synthase activity of cloned murine microglial cells.

@article{Corradin1993InducibleNO,
  title={Inducible nitric oxide synthase activity of cloned murine microglial cells.},
  author={Sally Corradin and Jacques Mau{\"e}l and Silvia Donini and Emilia Quattrocchi and Paola Ricciardi-Castagnoli},
  journal={Glia},
  year={1993},
  volume={7 3},
  pages={255-62}
}
Nitric oxide (NO) is a short-lived diffusable molecule now believed to participate in multiple physiologic functions in the CNS including neurotransmission and the maintenance of vascular tone. Previously, we reported that cell lines obtained by retroviral immortalization of tissue macrophages (M phi) could be induced to synthesize nitrite (NO2-), a stable end product of the NO synthetic pathway. We have further characterized the induction and activity of this pathway in a panel of seven… CONTINUE READING