Inducible nitric oxide synthase: Good or bad?

  title={Inducible nitric oxide synthase: Good or bad?},
  author={Maggie Lind and A. H. Hayes and Martin {\vC}aprnda and Daniel Petrovi{\vc} and Luis Rodrigo and Peter Kruzliak and Anthony Zulli},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss… CONTINUE READING