Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice.

@article{Perrone2013InducibleNO,
  title={Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice.},
  author={Lucy A. Perrone and Jessica A. Belser and Debra A. Wadford and Jacqueline M. Katz and Terrence M. Tumpey},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={207 10},
  pages={1576-84}
}
Highly pathogenic influenza A viruses, including avian H5N1 viruses and the 1918 pandemic virus, cause severe respiratory disease in humans and animals. Virus infection is followed by intense pulmonary congestion due to an extensive influx of macrophages and neutrophils, which can release large quantities of reactive oxygen species potentially contributing to the pathogenesis of lung disease. Here, the role of nitric oxide (NO), a potent signaling molecule in inflammation, was evaluated… CONTINUE READING
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Comments on the Pathology and Bavteriology of Fatal Influenza Cases, as Observed at Camp Devins, Mass. Bulletin of the Johns Hopkins Hospital 1919; 338(April):104-9

  • SB Wolbach
  • C IR O L irary Sevices on Feruary 20,
  • 2013
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