Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells.

@article{Lepper2010InducibleLT,
  title={Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells.},
  author={Christoph Lepper and C O Fan},
  journal={Genesis},
  year={2010},
  volume={48 7},
  pages={424-36}
}
We have generated a mouse strain carrying a Cre-ER(T2) knock-in allele at the Pax7 locus, the Pax7(CE) allele (Lepper et al., 2009, Nature 460:627-631). Combining Pax7(CE) and the R26R(LacZ) Cre reporter allele, here we describe temporal-specific tamoxifen (tmx)-inducible lineage tracing of embryonic Pax7-expressing cells. In particular, we focus on the somitic lineage. Tmx-inducible Cre activity directed by the Pax7(CE) allele is similar to the endogenous Pax7 expression pattern. The somitic… CONTINUE READING

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