Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

@article{Vane1994InducibleIO,
  title={Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.},
  author={J. Vane and J. Mitchell and I. Appleton and A. Tomlinson and D. Bishop-Bailey and J. Croxtall and D. Willoughby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 6},
  pages={
          2046-50
        }
}
  • J. Vane, J. Mitchell, +4 authors D. Willoughby
  • Published 1994
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an inducible (COX-2) enzyme. Nitric oxide is derived from L-arginine by isoforms of nitric-oxide synthase (NOS; EC 1.14.13.39): constitutive (cNOS; calcium-dependent) and inducible (iNOS; calcium-independent). Here we have investigated inducible isoforms of COX and NOS in the acute, chronic, and resolving stages of a murine air… CONTINUE READING
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