Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1).

@article{Li2013InducibleI3,
  title={Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1).},
  author={Yongkui Li and Jiajia Xie and Xiupeng Xu and Li Liu and Yushun Wan and Yingle Liu and Chengliang Zhu and Ying Zhu},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 29},
  pages={20927-41}
}
Interleukin (IL)-32 has been recognized as a proinflammatory cytokine that participates in responses to viral infection. However, little is known about how IL-32 is induced in response to viral infection and the mechanisms of IL-32-mediated antiviral activities. We discovered that IL-32 is elevated by hepatitis B virus (HBV) infection both in vitro and in vivo and that HBV induced IL-32 expression at the level of both transcription and post-transcription. Furthermore, microRNA-29b was found to… CONTINUE READING
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