Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.

@article{Mycko2004InducibleHS,
  title={Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.},
  author={Marcin P. Mycko and Hanna {\'C}wiklińska and Jacek Szymański and Bożena Szymańska and Grzegorz Kudla and Lukasz Kilianek and Artur Odyniec and Celia F. Brosnan and Krzysztof W. Selmaj},
  journal={Journal of immunology},
  year={2004},
  volume={172 1},
  pages={202-13}
}
In this study, we investigated the role of the inducible form of heat shock protein 70 (hsp70) in the presentation of the major putative autoantigen in multiple sclerosis, myelin basic protein (MBP), in the context of appropriate MHC class II. By coimmunoprecipitation, we found that MBP is associated with hsp70 in APC in an ATP/ADP-dependent manner. Additionally, using confocal microscopy, hsp70 was detected in the endocytic pathway of APC, where it colocalized with MBP and HLA-DR. The… CONTINUE READING