Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.

@article{Tao2009InducibleHS,
  title={Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.},
  author={Yun Tao and John P Hart and Lev Lichtenstein and Loren J Joseph and Mae J. Ciancio and Shien Hu and Eugene B Chang and Marc Bissonnette},
  journal={Carcinogenesis},
  year={2009},
  volume={30 1},
  pages={175-82}
}
BACKGROUND Heat shock protein 70 (Hsp70) regulates protein biosynthesis and refolding of denatured proteins. Since Hsp70 participates in recovery from stress injury, we examined the effect of Hsp70 genetic deletion in the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of inflammation and colon cancer. METHODS Hsp70 mutant mice (Hsp70.1(-/-)/70.3(-/-)) and wild-type (WT) littermates received AOM and three cycles of DSS and were killed 24 weeks later. Tumors were graded for histology and… CONTINUE READING

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