Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system.

@article{Ho1996InducibleGE,
  title={Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system.},
  author={Dora Y. Ho and John R McLaughlin and Robert Morris Sapolsky},
  journal={Brain research. Molecular brain research},
  year={1996},
  volume={41 1-2},
  pages={200-9}
}
Herpes simplex virus-based amplicon vectors have been used for gene transfer into cultured neurons and the adult CNS. Since constitutive expression of a foreign gene or overexpression of an endogenous gene may have deleterious effects, the ability to control temporal expression would be advantageous. To achieve inducible gene expression, we have incorporated the tetracycline-responsive promoter system into amplicon vectors and showed, both in vitro and in vivo, that expression can be modulated… CONTINUE READING

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