Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment.

@article{OhnoMatsui2002InducibleEO,
  title={Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment.},
  author={K. Ohno‐Matsui and A. Hirose and S. Yamamoto and J. Saikia and N. Okamoto and P. Gehlbach and E. Duh and S. Hackett and M. Chang and D. Bok and D. Zack and P. Campochiaro},
  journal={The American journal of pathology},
  year={2002},
  volume={160 2},
  pages={
          711-9
        }
}
  • K. Ohno‐Matsui, A. Hirose, +9 authors P. Campochiaro
  • Published 2002
  • Biology, Medicine
  • The American journal of pathology
  • Transgenic mice with vascular endothelial growth factor (VEGF) driven by the rhodopsin promoter (rho/VEGF mice) develop neovascularization that originates from the deep capillary bed of the retina and grows into the subretinal space. In rho/VEGF mice, VEGF expression in photoreceptors begins between postnatal days 5 and 7, the period when the deep capillary bed is developing. An important question is whether or not the developmental stage of the deep capillary bed is critical for occurrence of… CONTINUE READING
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