Inducible expression of the long pentraxin PTX3 in the central nervous system

@article{Polentarutti2000InducibleEO,
  title={Inducible expression of the long pentraxin PTX3 in the central nervous system},
  author={Nadia Polentarutti and Barbara Bottazzi and Elena Di Santo and Elisabetta Blasi and Alberto Mantovani},
  journal={Journal of Neuroimmunology},
  year={2000},
  volume={106},
  pages={87-94}
}
PTX3 is a prototypic long pentraxin consisting of a C terminal 203-amino acid pentraxin-like domain coupled with an N-terminal 178-amino acid unrelated portion. PTX3 is induced by primary proinflammatory signals in various cell types, most prominently macrophages and endothelial cells. Other long pentraxins, such as murine or rat neuronal pentraxin 1 (NP1) and human neuronal pentraxin 2 (NPTX2), are expressed in the central nervous system (CNS). The present study was designed to investigate… CONTINUE READING

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