Inducible expression of noggin selectively expands neural progenitors in the adult SVZ.

@article{Morell2015InducibleEO,
  title={Inducible expression of noggin selectively expands neural progenitors in the adult SVZ.},
  author={Maria Cecilia Morell and Yao-chang Tsan and KarenM. O'Shea},
  journal={Stem cell research},
  year={2015},
  volume={14 1},
  pages={
          79-94
        }
}
Multipotent, self-renewing stem cells are present throughout the developing nervous system remaining in discrete regions of the adult brain. In the subventricular zone (SVZ) signaling molecules, including the bone morphogenetic proteins and their secreted inhibitor, noggin appear to play a critical role in controlling neural stem cell (NSC) behavior. To examine the function of this signaling pathway in the intact nervous system, we developed a transgenic mouse model in which noggin expression… CONTINUE READING
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