Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity.

@article{Narumi1991InducibleEO,
  title={Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity.},
  author={Shosaku Narumi and Thomas A Hamilton},
  journal={Journal of immunology},
  year={1991},
  volume={146 9},
  pages={3038-44}
}
We have examined the expression of inducible inflammatory genes in murine macrophages from different tissues and at different stages of inflammatory activity. Although i.v. administration of IFN-gamma (10,000 U/mouse) strongly induced expression of IP-10 mRNA in the adherent cell population of the spleen, thioglycollate-elicited peritoneal macrophages were essentially unresponsive at the same dose. In contrast, D3 mRNA was expressed in both cell populations. This differential sensitivity of IP… CONTINUE READING
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