Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.

@article{Huettner2003InducibleEO,
  title={Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.},
  author={Claudia S. Huettner and Steffen Koschmieder and Hiromi Iwasaki and Junko Iwasaki-Arai and Hanna S. Radomska and Koichi Akashi and Daniel Geoffrey Tenen},
  journal={Blood},
  year={2003},
  volume={102 9},
  pages={
          3363-70
        }
}
The BCR/ABL fusion protein is found in more than 90% of patients with chronic myeloid leukemia (CML) as well as in a subset of patients with acute B-cell leukemia. We have previously described a transgenic model for an inducible and reversible acute B-cell leukemia caused by p210 BCR/ABL. Here, we describe a new model of an inducible BCR/ABL disease by directing the expression of the oncogene to megakaryocytic progenitor cells within the murine bone marrow using the tetracycline-responsive… 

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