Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis

@article{Lu2006InducibleEO,
  title={Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis},
  author={Yuning Lu and Y-b Xu and T-T Yuan and M-G Song and Michael Luebbert and Manfred Fliegauf and G Chen},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={987-993}
}
AML1-ETO, a leukemia-associated fusion protein generated by the frequently occurred chromosome translocation t(8;21) in acute myeloid leukemia, was shown to exert dichotomous functions in leukemic cells, that is, growth arrest versus differentiation block. By the analysis of oligonucleotide microarray, AML1-ETO was shown to modulate the expressions of an impressive array of pro- and anti-apoptotic genes. Here, we investigate potential effects of the ecdysone inducible AML1-ETO expression on… CONTINUE READING