Inducible expression eliminates the fitness cost of vancomycin resistance in enterococci.

Abstract

Inducible vancomycin resistance in enterococci is due to a sophisticated mechanism that combines synthesis of cell wall peptidoglycan precursors with low affinity for glycopeptides and elimination of the normal target precursors. Although this dual mechanism, which involves seven genes organized in two operons, is predicted to have a high fitness cost… (More)
DOI: 10.1073/pnas.1006855107

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