Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

@article{Gigoux2009InducibleCP,
  title={Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.},
  author={Mathieu Gigoux and Jijun Shang and Youngshil Pak and Minghong Xu and Jongseon Choe and Tak W Mak and Woong-Kyung Suh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 48},
  pages={20371-6}
}
The T-cell costimulatory receptors, CD28 and the inducible costimulator (ICOS), are required for the generation of follicular B helper T cells (T(FH)) and germinal center (GC) reaction. A common signal transducer used by CD28 and ICOS is the phosphoinositide 3-kinase (PI3K). Although it is known that CD28-mediated PI3K activation is dispensable for GC reaction, the role of ICOS-driven PI3K signaling has not been defined. We show here that knock-in mice that selectively lost the ability to… CONTINUE READING

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Targeted knockin mice expressing mutations of CD28 reveal an essential pathway for costimulation

LF Dodson
Mol Cell Biol • 2009

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